Ataxia - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications

By Icon Health Publications

This can be a 3-in-1 reference e-book. It provides an entire clinical dictionary masking thousands of phrases and expressions when it comes to ataxia. It additionally supplies broad lists of bibliographic citations. eventually, it offers details to clients on how one can replace their wisdom utilizing numerous web assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with study devoted to ataxia. in case your time is efficacious, this booklet is for you. First, you won't waste time looking the net whereas lacking loads of appropriate info. moment, the publication additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing 1000s of websites.

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Purkinje cells cultured from 0-1 day old SCA-1 transgenic mice will be used to determine if cultured Purkinje cells expressing mutant ataxin-1 show (i) altered expression of calcium binding proteins and proteins involved in calcium signaling (ii) sensitivity to increased Ca 2+-influx (iii) altered response to the inhibitors of calcium-dependent proteases and (iv) if treatment with IGF-I can reverse ataxin-1 mediated pathological changes. Purkinje cell cultures from non-transgenic mice will be used as controls.

Professor; Genetics, Cell Biology & Develpmnt; University of Minnesota Twin Cities 200 Oak Street Se Minneapolis, Mn 554552070 Timing: Fiscal Year 2002; Project Start 16-JUN-2000; Project End 31-MAY-2005 Summary: (adapted from applicant's abstract): The investigator recently cloned a CTG expansion that causes a novel form of spinocerebellar ataxia (SCA8) and demonstrated that the repeat is transcribed in the CTG-orientation, as in myotonic dystrophy, but not the CAG-orientation, as reported for all of the other SCAs.

Also, the fidelity of transcription will be monitored along with the effects of Studies 25 transcription on repeat stability. Our new data revealed the inhibitory effects of expanded intronic genetic instabilities of the FRDA triplet repeat sequences (TRS) in vivo and vitro. TTC and their effect on transcription and on genetic instabilities (replication and recombination). ; Professor; Pediatrics; University of Minnesota Twin Cities 200 Oak Street Se Minneapolis, Mn 554552070 Timing: Fiscal Year 2002; Project Start 10-JAN-1995; Project End 31-DEC-2003 Summary: The central theme of this program is to exploit recent advances in basic science for t he development of innovative gene therapy strategies, especially for metabolic disorders causing mental retardation.

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