Applications of Biotechnology in Oncology by Kewal K. Jain

By Kewal K. Jain

Applications of Biotechnology in Oncology collects key writings via Kewal ok. Jain at the most vital contributions of biotechnology to melanoma learn, fairly to the molecular prognosis of melanoma and drug supply in melanoma for custom-made administration of sufferers. fundamentals of varied “omics” applied sciences and their software in oncology are defined as oncogenomics and oncoproteomics. This precise quantity additionally explores molecular diagnostics, nanobiotechnology, telephone and gene remedies, in addition to customized oncology. With nearly a thousand chosen references from fresh literature in this subject and various tables and figures, Applications of Biotechnology in Oncology serves as an incredible reference for oncologists, scientists fascinated about study on melanoma biology, and physicians in quite a few specialties who care for cancer.

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2 Ion Channels and Cancer Ion channels are protein pores in the cell membrane that allow the passage of ions down their respective electrochemical gradients. 1 Ion channels involved in development of cancer Ion channel VGKCs VGSCs VGCCs Effect on cancer cell lines Tumor progression and invasion Metastatic carcinoma Prostate cancer Small-cell lung cancer TRPM1 Melanoma TRPM7 Glioma TRPM8 Prostate, breast, lung, and skin cancers TRPV Colorectal and prostate carcinoma Based on data from Li and Xiong (2011) Mechanism Cell proliferation Cell motility Cell differentiation Cell motility Cell growth Cell proliferation Proliferation and apoptosis Cell proliferation and the mechanisms by which they are opened or closed.

Cells normally employ autophagy temporarily to survive when nutrients are short, to recycle components to form new organelles, or to fend off viral or bacterial infection. In cancer research, there is evidence both that autophagy is a form of programmed cell death triggered to prevent the replication of damaged cells and that cancer cells in some instances employ it to survive attack. Insights into the molecular mechanisms of autophagy are now leading to the discovery of exciting new potential drug targets.

Fas is a cell surface receptor of tumor necrosis factor (TNF) receptor family. Triggering of Fas by its ligand, FasL, causes apoptosis, provided the cells are sensitized to the Fas signal. For the latter approach, better methods of gene targeting will be needed to replace proapoptotic genes in tumors. Increase of apoptosis by inhibition of nuclear factor kappa B (NF-κB). The transcription factor NF-κB is activated by chemotherapy and by irradiation in some cancer cell lines and is the principal mechanism of inducible tumor chemoresistance.

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