Antiviral Drug Development: A Multidisciplinary Approach by Richard T. Walker (auth.), Erik De Clercq, Richard T. Walker

By Richard T. Walker (auth.), Erik De Clercq, Richard T. Walker (eds.)

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The potential of nucleosides and nucleotides and their analogs against retroviruses was reviewed by Robins(133) in 1984. 2',3'-Dideoxythymidine 5'-phosphate was first shown by Baltimore and coworkers(134) to inhibit reverse transcriptase from avian myeloblastosis virus. This inhibition is 100-fold greater than the inhibition of cellular «-DNA polymerase(135). Studies of 2',3'-dideoxyadenosine, 23, first prepared in our laboratory(136) in 1964, have shown significant-rnhibition of the retrovirus 334C M~LV in NIH Swiss 3T3 cells in culture(137).

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