Alzheimer's disease and related disorders annual, 2002 by Jeffrey L Cummings, Serge Gauthier

By Jeffrey L Cummings, Serge Gauthier

Given the improvement of recent healing recommendations and items, Serge Gauthier and Jeffrey Cummings have compiled a listing of up to date subject matters so that it will be of curiosity basically to neurologists targeting Alzheimer's ailment, and in addition to psychiatrists and geriatricians. The participants, all revered of their subspecialties, have written updated, comprehensively referenced chapters which should supply information in addition to stimulate dialogue on the place present remedy is heading.

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Alzheimer's disease and related disorders annual, 2002

Given the advance of recent healing concepts and items, Serge Gauthier and Jeffrey Cummings have compiled a listing of up to date issues with a view to be of curiosity basically to neurologists concentrating on Alzheimer's sickness, and likewise to psychiatrists and geriatricians. The members, all revered of their subspecialties, have written up to date, comprehensively referenced chapters which should supply tips in addition to stimulate dialogue on the place present remedy is heading.

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36 However, even the detection of activated enzyme does not assure that the enzyme is active in the cell. 18,37 The certain way to ascertain whether these caspases are active in the cell is by the use of specific cell permeant fluorogenic substrates, compounds that have not yet been designed. Even so, the approach is not possible in postmortem tissue, leaving uncertainty about how to interpret immunohistologic evidence of caspase activation in AD brain tissue. Model systems such as cultured cells and transgenic animals can provide some insight into which of the multiple changes seen in tissue is central to the disease process and which are peripheral.

Ivins KJ, Thornton PL, Rohn TT, Cotman CW. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Neurobiol Dis 1999; 6:440–449. 50. Nakagawa T, Zhu H, Morishima N et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403:98–103. 51. Yoshida H, Kong YY, Yoshida R et al. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 1998; 94:739–750. 52. Cecconi F, Alvarez-Bolado G, Meyer BI et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.

Rohn TT, Head E, Su JH et al. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer’s disease. Am J Pathol 2001; 158:189–198. 33. Su JH, Zhao M, Anderson AJ et al. Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology. Brain Res 2001; 898:350–357. 34. Stefanis L, Park DS, Yan CY et al. Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis. J Biol Chem 1996; 271:30663– 30671.

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