Ageing: Lessons from C. elegans by Anders Olsen, Matthew S. Gill

By Anders Olsen, Matthew S. Gill

This booklet brings jointly in a single quantity the present nation of ageing examine within the nematode Caenorhabditis elegans. The authors are best researchers within the box, putting this subject within the context of human aging, describing how and why uncomplicated discoveries during this basic organism have impacted our clients for intervention within the growing old strategy. The authors hide a vast variety of themes near to organismal and reproductive growing older together with anatomical, physiological and biochemical alterations, in addition to genetic and environmental interventions that advertise sturdiness and ameliorate age-related disorder. growing older is the only most vital issue opting for the onset of human ailment in constructed nations. With present around the globe demographic developments indicating that the variety of participants over the age of sixty five will proceed to upward push, it really is transparent that an realizing of the procedures that underpin getting older and age-related affliction represents a key problem within the biomedical sciences. lately there were large advances in our knowing of the getting old technique and lots of of those have stemmed from genetic research of C. elegans.

With no analogous e-book during this topic region this paintings can be of curiosity to a large viewers, starting from educational researchers to the final public.

Show description

Read or Download Ageing: Lessons from C. elegans PDF

Best geriatrics books

Dementia: Mind, Meaning, and the Person

Dementia is an disease that increases vital questions about our personal attitudes to ailment and getting older. It additionally increases vitally important concerns past the limits of dementia to do with how we expect of ourselves as humans - basic questions about own identification. Is the individual with dementia an identical individual she or he was once sooner than?

Eldercare Technology for Clinical Practitioners (Aging Medicine)

This significant instruction manual addresses applied sciences exact on the overview, early detection and the mitigation of universal geriatric stipulations. those contain decline in practical skills, gait, mobility, sleep disturbance, imaginative and prescient impairment, listening to loss, falls, and cognitive decline. This e-book not just describes the country of either embedded and wearable applied sciences, but in addition specializes in learn exhibiting the capability application of those applied sciences within the box.

Alzheimer's disease and related disorders annual, 2002

Given the advance of recent healing innovations and items, Serge Gauthier and Jeffrey Cummings have compiled a listing of latest issues so one can be of curiosity basically to neurologists targeting Alzheimer's illness, and likewise to psychiatrists and geriatricians. The members, all revered of their subspecialties, have written up to date, comprehensively referenced chapters which should offer tips in addition to stimulate dialogue on the place present remedy is heading.

Dementia Care: An Evidence-Based Approach

This publication presents an summary of the demographic, medical, and psychosocial context of dementia care. With its specialize in sufferer and relatives views, this ebook describes evidence-based ways in the direction of prevention, detection, and therapy of dementia that's like several different booklet. The textual content offers reminiscence clinics, care administration, home-based interventions, palliative care, relations caregiver courses, particular to dementia care.

Extra info for Ageing: Lessons from C. elegans

Sample text

At its anterior end, the intestine is connected to the pharynx via the pharyngeal valve. The most posterior portion is squeezed by the stomatointestinal muscle (not shown), near where the intestine connects to the rectum and anus. Arrowhead indicates the position of the TEM cross-section shown in (c) (Adapted with permission from [58]). (b) Key structural elements of the healthy intestinal cytoskeleton. At its basal pole the intestine is covered by a basal lamina (orange), separating it from the pseudocoelom.

Bar, 1 μm. (g) The microvillar border and the terminal web (arrow) separating the lumen from the intestinal cytoplasm are less electron dense and possibly incomplete, allowing bacteria to invade the intestinal cell cytoplasm (Image source: [Hall] N831 W006). Bar, 1 μm. (h) The bacteria -filled lumen (L) (right) and the intestinal cytoplasm (left) seem to be in direct contact along an ill-defined interface, with no obvious structure to divide them (Image source: [Hall] N833 W090). Bar, 1 μm uterus or spermatheca or cross into cell cytoplasm along the alimentary canal, infecting the marginal cells of the pharynx [50].

Simultaneous knock-down of ins-4, ins-6, and daf-28 generates a fully penetrant Daf-c phenotype suggesting that these insulin peptides are the principle regulators of reproductive growth [68], and these ligands are hypothesized to act as agonist ligands for DAF-2. Human insulin, when expressed transgenically in C. elegans, appears to act as a DAF-2 antagonist and enhances dauer formation [61]. INS-1 and INS-18 are structurally most similar to human insulin and also appear to act as antagonists [61, 68].

Download PDF sample

Rated 4.86 of 5 – based on 37 votes